Sirolimus by LCMSMS
General Information
- Lab Name
- Sirolimus by LCMSMS
- Lab Code
- SIROLG
- Epic Name
- Sirolimus Level
- Description
The concentration of sirolimus in whole blood is determined by liquid chromatography-tandem mass spectrometry after protein precipitation. The reportable range is 1.0 to 700.0 ng/mL with imprecision of less than 11 %CV.
- Synonyms
- Rapamune, Rapamycin, Sirol
- Components
-
Code Name SIROL Sirolimus SIRINF Sirolimus Information
Interpretation
- Method
Whole blood protein precipitation. Analysis by liquid chromatography - tandem mass spectrometry.
- Reference Range
- See individual components
- Ref. Range Notes
Whole blood trough Sirolimus concentrations of 5 - 15 ng/mL are effective in reducing the incidence of acute rejection in renal transplant patients when Sirolimus is used as part of a combined immunosuppressive regimen.
Ordering & Collection
- Specimen Type
- whole blood
- Collection
-
3 mL blood in a Lavender top tube. Trough specimen preferred
- Quantity
-
Requested: entire sample
Minimum: 1.5 mL whole blood for 3 mL Lavender Liquid EDTA (K3 EDTA); 0.5 mL whole blood for 3 mL Lavender Dry EDTA (K2 EDTA)
Processing
- Receiving Instructions
Refrigerate whole blood, do not centrifuge.Frozen sample acceptable - Do not repeat freeze-thaw cycle
Outside laboratories: transport specimen at 2-8 oC
Stability: Room temp: 2d; Refrig: 5 d
- Misc Sendout
Performance
- Lab Department
- Chemistry, University(CHU)
- Frequency
- Daily, specimen in UW chemistry lab by 1:00 pm results by 4:30pm.
- Available STAT?
- No
- Performing Location(s)
-
UW-MT Chemistry, Special
206-520-4600Clinical Lab, Room NW220,
University of Washington Medical Center,
1959 NE Pacific street, Seattle, WA 98195
Billing & Coding
- CPT Codes
- 80195
- LOINC
- 29247-4
- Interfaced Order Code
- UOW2750