Nicotine and Metabolites, Urine (Sendout)
General Information
- Lab Name
- Nicotine and Metabolites, URN
- Lab Code
- RUNIC
- Epic Ordering
- Nicotine And Metabolites, Urine (Sendout)
- External Test Id
- NICOU
- Description
Useful For:
- Monitoring tobacco use
- Monitoring patients on nicotine-replacement therapy for concurrent use of tobacco products
- References
- Mayo Clinical & Interpretive Information: Nicotine and Metabolites, Random, Urine
- Synonyms
- Anabasine, Cotinine, NICOU, Nornicotine, Tobacco Alkaloids
- Components
-
Code Name RUNICO Nicotine, URN RUCOTI Cotinine, URN RUNNIC Nornicotine, URN RUANAB Anabasine, URN
Interpretation
- Method
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
- Reference Range
- See individual components
- Ref. Range Notes
Reference Values (Non-tobacco user with no passive exposure):
Nicotine, Urine: <5.0 ng/mL Cotinine, Urine: <5.0 ng/mL Anabasine, Urine: <2.0 ng/mL Nornicotine, Urine: <2.0 ng/mL Interpretation:
Urine nicotine in the range of 1000 to 5000 ng/mL with cotinine in the range of 1000 to 8000 ng/mL indicates the subject is either actively using a tobacco product or on high-dose nicotine patch therapy.
The presence of anabasine and nornicotine indicates a subject on patch therapy who is actively using a tobacco product.
Typical findings are as follows:
While using a tobacco product:
- Peak nicotine concentration: 1000 to 5000 ng/mL
- Peak cotinine concentration: 1000 to 8000 ng/mL
- Anabasine concentration: 10 to 500 ng/mL
- Nornicotine concentration: 30 to 900 ng/mL
Tobacco user after 2 weeks complete abstinence:
- Nicotine concentration: <30 ng/mL
- Cotinine concentration: <50 ng/mL
- Anabasine concentration: <2.0 ng/mL
- Nornicotine concentration: <2.0 ng/mL
Nontobacco user with passive exposure:
- Nicotine concentration: <20 ng/mL
- Cotinine concentration: <20 ng/mL
- Anabasine concentration: <2.0 ng/mL
- Nornicotine concentration: <2.0 ng/mL
Nontobacco user with no passive exposure:
- Nicotine concentration: <5.0 ng/mL
- Cotinine concentration: <5.0 ng/mL
- Anabasine concentration: <2.0 ng/mL
- Nornicotine concentration: <2.0 ng/mL
- Interferences and Limitations
Cautions: Knowledge of time elapsed between last dose and specimen collection is important for interpretation of test results.
- References
- Mayo Clinical & Interpretive Information: Nicotine and Metabolites, Random, Urine
Ordering & Collection
- Specimen Type
- Urine
- Collection
-
Random urine collected in a preservative-free collection container
- Handling Instructions
Outside Laboratories: Transfer 3 mL urine (1 mL minimum) into a separate aliquot and refrigerate.
Stability: Refrigerated: 28 days; Frozen: 365 days; Ambient: 28 days.
- Quantity
-
requested: 3 mL Urine
minimum: 2 mL Urine
Processing
- Processing
Transfer 3 mL urine (1 mL minimum) into a separate screw-cap plastic aliquot. Refrigerate sample.
Sendouts:
- Order Mayo Test: NICOU.
- Interfaced: Yes [Interface: 601; Department: MARF]
Stability: Refrigerated: 28 days; Frozen: 365 days; Ambient: 28 days.
Performance
- LIS Dept Code
- Sendouts Mayo Lab (RF) (MARF)
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-17103050 Superior Drive NW
Rochester, MN 55901 - Frequency
- Performed: Monday through Thursday. Report Available: 2-5 days from sample receipt at Mayo.
- Available STAT?
- No
Billing & Coding
- CPT codes
- G0480
- LOINC
- 43125-4
- Interfaced Order Code
- UOW2349