Toxocariasis Antibody (Sendout)

Interpretation

Method

Enzyme-Linked Immunosorbent Assay (ELISA)

Reference Range

See individual components

Ref. Range Notes

Interpretation:

Positive:	IgG antibodies to Toxocara species detected, suggesting current or past infection.*
Equivocal:	Recommend follow-up testing in 10 to 14 days if clinically indicated.
Negative:	No antibodies to Toxocara species detected.

*False-positive results may occur in patients with other helminth infections (eg, Ascaris lumbricoides, Schistosoma species, Strongyloides).

Interferences and Limitations

Cautions:

A single negative result does not rule out infection. Assay sensitivity may be decreased depending on the site of infection, in cases of low parasitic burden, and timing of sample collection relative to exposure. In ocular toxocariasis, Toxocara antibody levels in serum can be low or absent despite clinical disease. Repeat testing should be considered in patients who are at high risk of exposure or infection.

False-negative results may occur in severely immunosuppressed patients.

Positive results should be interpreted with patient's clinical status and exposure history.

Positive results by this assay do not distinguish acute versus remote infection.

False-positive results may occur in patients with other helminth infections.

This assay uses synthetic antigens derived from Toxocara canis. Studies evaluating the sensitivity of this assay in patients infected with Toxocara cati have not been performed.

References

• Mayo Clinical and Interpretive Information: Toxocara Antibody, IgG, Serum

Ordering & Collection

Specimen Type

Blood

Collection

3 mL blood in RED TOP tube or GOLD SST

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C while awaiting shipment. Transport samples on dry ice.

Stability: Frozen (preferred): 30 days; Refrigerated: 5 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, heat-inactivated specimen.

Quantity

Requested: 0.5 mL serum
Minimum: 0.4 mL serum

Processing

Receiving Instructions

Centrifuge sample and transfer serum to a separate plastic vial. Freeze serum at -20°C.

Sendouts:

• Order Mayo Test: TOXCG.
• Interfaced: Yes.

Stability: Frozen (preferred): 30 days; Refrigerated: 5 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, heat-inactivated specimen

Misc Sendout

Performance

Lab Department

Sendouts Mayo Lab (FZ)(MAFZ)

Frequency

Performed: Tuesday, Thursday. Report Available: 1-5 days.

Available STAT?

No

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901

Billing & Coding

CPT Codes

86682

LOINC

40674-4

Interfaced Order Code

UOW5018