S. pneumoniae IgG Antibody, 23 Serotypes (Sendout)

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General Information

Lab Name
S. pneumoniae IgG Antibody, 23 Serotypes (Sendout)
Lab Code
RSP23
Epic Ordering
S pneumoniae IgG Antibodies, 23 Serotypes (Sendout)
External Test Id
PN23M
Description

Useful For:

  • Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent pneumococcal vaccines
  • Assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent and 20-valent pneumococcal vaccines
  • Determining the ability of an individual to produce an antibody response to polysaccharide antigens, as part of the evaluation for humoral or combined immunodeficiencies

Ordering Guidance: This test is the preferred test for patients previously tested for Streptococcus pneumoniae serotypes (as part of follow up testing or part of pre/post vaccine assessment).

***Order Alert: Effective 01/31/2025, Serotype 19A (57) is not being reported due to reagent issues at Mayo Clinical Laboratories. An adequate response to pneumococcal vaccination is generally thought to be demonstrated when a patient shows response to at least 50% of the serotypes in the PN23M assay. For most patients, this can be assessed even if only 22 serotypes are reported.***

Synonyms
PN23, PN23M, Pneumococcal Antibody (IgG) 23 Serotype Panel, Strep Pneumoniae Antibody, Strep Vaccine, Streptococcus Pneumoniae
Components

Interpretation

Method

Microsphere Photometry

Reference Range
See individual components
Interferences and Limitations

Cautions:

The humoral immune response to Streptococcus pneumoniae is age dependent and the database of IgG antibody concentrations to different serotypes is incomplete.

Protective concentrations of IgG antibodies, or those required to prevent infection from S pneumoniae, have not been defined for any serotype.

Quantitation of the IgG antibody response to pneumococcal serotypes does not provide any information on the functional capacity of the serotype-specific antibodies generated (opsonization efficiency).

Ordering & Collection

Specimen Type
Serum
Collection

3 mL blood in RED TOP tube or GOLD SST

Unacceptable: Any other tube type

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Quantity
requested: 0.5 mL serum
minimum: 0.4 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

  • Order Mayo Test: PN23M.
  • Interfaced: Yes.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Performance

LIS Dept Code
Sendouts Mayo Lab (RF) (MARF)
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901
Frequency
Performed: Monday - Friday. Report Available: 4 - 6 days.
Available STAT?
No

Billing & Coding

CPT codes
86581
LOINC
42366-5
Interfaced Order Code
UOW2392