S. pneumoniae IgG Antibody, 23 Serotypes (Sendout)

General Information

Lab Name

Lab Code

RSP23

Epic Ordering

S pneumoniae IgG Antibodies, 23 Serotypes (Sendout)

External Test Id

PN23M

Description

Useful For:

Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent pneumococcal vaccines
Assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent and 20-valent pneumococcal vaccines
Determining the ability of an individual to produce an antibody response to polysaccharide antigens, as part of the evaluation for humoral or combined immunodeficiencies

Ordering Guidance: This test is the preferred test for patients previously tested for Streptococcus pneumoniae serotypes (as part of follow up testing or part of pre/post vaccine assessment).

Synonyms

PN23, PN23M, Pneumococcal Antibody (IgG) 23 Serotype Panel, Strep Pneumoniae Antibody, Strep Vaccine, Streptococcus Pneumoniae

Components

Code	Name
RST1	Serotype 1 (1)
RST2	Serotype 2 (2)
RST3	Serotype 3 (3)
RST4	Serotype 4 (4)
RST5	Serotype 5 (5)
RST8	Serotype 8 (8)
RST9N	Serotype 9N (9)
RST12F	Serotype 12F (12)
RSTY14	Serotype 14 (14)
RST17F	Serotype 17F (17)
RST19F	Serotype 19F (19)
RSTY20	Serotype 20 (20)
RST22F	Serotype 22F (22)
RST23F	Serotype 23F (23)
RST6B	Serotype 6B (26)
RST10A	Serotype 10A (34)
RST11A	Serotype 11A (43)
RST7F	Serotype 7F (51)
RST15B	Serotype 15B (54)
RST18C	Serotype 18C (56)
RST19A	Serotype 19A (57)
RST9V	Serotype 9V (68)
RST33F	Serotype 33F (70)
RSP23I	S. pneumoniae IgG Antibody, 23 Serotypes Interpretation

Interpretation

Method: Microsphere Photometry
Reference Range: See individual components
Interferences and Limitations: Cautions:

The humoral immune response to Streptococcus pneumoniae is age dependent and the database of IgG antibody concentrations to different serotypes is incomplete.

Protective concentrations of IgG antibodies, or those required to prevent infection from S pneumoniae, have not been defined for any serotype.

Quantitation of the IgG antibody response to pneumococcal serotypes does not provide any information on the functional capacity of the serotype-specific antibodies generated (opsonization efficiency).

Ordering & Collection

Specimen Type: Serum
Collection: 3 mL blood in RED TOP tube or GOLD SST

Unacceptable: Any other tube type
Handling Instructions: Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.
Quantity: requested: 0.5 mL serum
minimum: 0.4 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Sendouts:

Order Mayo Test: PN23M.
Interfaced: Yes.

Stability: Refrigerated (preferred): 21 days; Frozen: 21 days; Ambient: Unacceptable.

Performance

LIS Dept Code

Sendouts Mayo Lab (RF) (MARF)

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901

Frequency

Performed: Monday - Friday. Report Available: 4 - 6 days.

Available STAT?

Billing & Coding

CPT codes: 86317x23
LOINC: 42366-5
Interfaced Order Code: UOW2392