Bile Acids, Fractionated and Total (Sendout)
General Information
- Lab Name
- Bile Acids, Fractionated and Total (Sendout)
- Lab Code
- RBAFTS
- Epic Name
- Bile Acids, Fractionated and Total (Sendout)
- External Test Id
- BAFS
- Description
Useful For:
- Measuring tauro- and glycol-conjugated and unconjugated bile acid constituents in serum specimens
- Monitoring patients receiving bile acid therapy, such as cholic acid, deoxycholic acid, or ursodeoxycholic acid
- Aiding in the evaluation of liver function; evaluation of liver function changes before the formation of more advanced clinical signs of illness such as icterus
- Determining hepatic dysfunction as a result of chemical and environmental injury
- Indicating hepatic histological improvement in chronic hepatitis C patients responding to interferon treatment
- Indicating intrahepatic cholestasis of pregnancy
- Note: This assay is not useful for the diagnosis of peroxisomal biogenesis disorders or inborn errors of bile acid metabolism.
Test Highlights:
- Bile acids are elevated in individuals with liver dysfunction.
- This bile acid test can be used in the diagnosis of intrahepatic cholestasis of pregnancy.
- Fractionated bile acids, including tauro- and glycol-conjugates of cholic acid, chenodeoxycholic acid, deoxycholic acid, and ursodeoxycholic acid are individually summed and reported.
Ordering Note: For total bile acids only, refer to test Bile Acids (Total) (Sendout) [RBILEA].
- References
- Mayo Clinical & Interpretive Information: Bile Acids, Fractionated and Total, Serum
- Synonyms
- BAFS, Chenodeoxycholic acid, Cholic acid, Deoxycholic acid, Fractionated bile acids, Ursodeoxycholic acid
- Components
-
Code Name RCHOLA Total Cholic Acid RCHENA Total Chenodeoxycholic Acid RDEOXA Total Deoxycholic Acid RURSOA Total Ursodeoxycholic Acid RTOTBA Total Bile Acids
Interpretation
- Method
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
- Reference Range
- See individual components
- Ref. Range Notes
Reference Values:
Total cholic acid: < or =5.00 nmol/mL Total chenodeoxycholic acid: < or =6.00 nmol/mL Total deoxycholic acid: < or =6.00 nmol/mL Total deoxycholic acid: < or =2.00 nmol/mL Total bile acids: < or =19.00 nmol/mL Interpretation: Total bile acids are metabolized in the liver and can serve as a marker for normal liver function. Increases in serum bile acids are seen in patients with acute hepatitis, chronic hepatitis, liver sclerosis, liver cancer, and intrahepatic cholestasis of pregnancy.
- Interferences and Limitations
Cautions: This test does not measure sulfated bile acids.
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
3 mL blood in GOLD SST or RED TOP tube
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum while awaiting shipment. Transport with a cold pack.
Stability: Refrigerated (preferred): 90 days; Frozen: 90 days; Ambient: 90 days.
- Quantity
-
Requested: 0.5 mL serum
Minimum: 0.3 mL serum
Processing
- Receiving Instructions
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Sendouts:
- Order Mayo Test: BAFS
- Interfaced: Yes [Interface: 601; Worksheet: MARF]
Stability: Refrigerated (preferred): 90 days; Frozen: 90 days; Ambient: 90 days.
- Misc Sendout
Performance
- Lab Department
- Sendouts Mayo Lab (RF)(MARF)
- Frequency
- Performed: Monday through Friday. Report Available: 3-5 days from sample receipt at Mayo Clinic Labs.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- CPT Codes
- 82542
- LOINC
- 43130-4
- Interfaced Order Code
- UOW5302