Alpha 2 Anti Plasmin (Sednout)

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General Information

Lab Name
Alpha_2 Anti Plasmin
Lab Code
RAPLAS
Epic Name
Alpha-2 Anti Plasmin
External Test Id
A2PI
Description

Useful For:

  • Diagnosing congenital alpha-2 plasmin inhibitor deficiencies (rare)
  • Providing a more complete assessment of disseminated intravascular coagulation, intravascular coagulation and fibrinolysis, or hyperfibrinolysis (primary fibrinolysis), when measured in conjunction with fibrinogen, fibrin D-dimer, fibrin degradation products, soluble fibrin monomer complex, and plasminogen
  • Evaluating liver disease
  • Evaluating the effects of fibrinolytic or antifibrinolytic therapy
Synonyms
A2PI, Alpha 2 Plasmin Inhibitor, Alpha-2 Plasmin Inhibitor, Antiplasmin Potential, Functional Antiplasmin, Plasmin Inhibitor
Components

Interpretation

Method

Chromogenic

Reference Range
Units: %
Female Male
AgeRange AgeRange
0-80-140 0-80-140

Effective date: 11/25/2010

Ref. Range Notes

Normal, full-term, and premature infants may have mildly decreased levels (> or =50%) which reach adult levels < or = 90 days postnatal. See Pediatric Hemostasis References section in Coagulation Guidelines for Specimen Handling and Procssing in Special Instructions.

Interferences and Limitations

Cautions: Alpha-2 plasmin inhibitor results are potentially affected by:

  • Heparin, unfractionated or low-molecular-weight >4 U/mL
  • Alpha-2-macroglobulin >7 mg/mL; potentially leading to a falsely-increased result
  • Hemoglobin >200 mg/dL
  • Bilirubin >20 mg/dL
  • Triglycerides >1000 mg/dL

Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

Ordering & Collection

Specimen Type
Blood
Collection

3 or 5 mL BLUE TOP (CITRATE) tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer plasma to a separate plastic vial. Centrifuge plasma for another 10 minutes and decant plasma to a separate vial, leaving 0.25 mL in the bottom of centrifuged vial. Freeze platelet-poor plasma at -20°C while awaiting shipment. Transport samples on dry ice.

Stability: Frozen (required): 14 days; Refrigerated: Unacceptable; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Quantity
Requested: 1 mL plasma
Minimum: 0.5 mL plasma

Processing

Receiving Instructions

Promptly forward specimen to the Coagulation bench for processing. Sample must be processed within 4 hours of collection.

Coagulation Bench: Double-spin the sample and aliquot 1 mL (0.5 mL min) plasma into a separate vial. Freeze at -20°C.

  • UW-MT: Place in the Sendouts Mayo Frozen rack.
  • HMC: Place in the frozen rack for UWMC Reference Sendouts (to be sent Cross Hospital).

Sendouts:

  • Order Mayo Test: A2PI.
  • Interfaced: Yes.

Stability: Frozen (required): 14 days; Refrigerated: Unacceptable; Ambient: Unacceptable.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (FZ)(MAFZ)
Frequency
Performed: Monday - Friday. Report Available: 3 - 7 days.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Billing & Coding

CPT Codes
85410
LOINC
27810-1