Amiodarone and Desethylamiodarone (Sendout)

General Information

Lab Name

Amiodarone, Desethylamiodarone

Lab Code

RAMIO

Epic Name

Amiodarone and Desethylamiodarone (Sendout)

External Test Id

AMIO

Description

Useful For:

Monitoring amiodarone therapy, especially when amiodarone is coadministered with other drugs that may interact
Evaluation of possible amiodarone toxicity
Assessment of patient compliance

Collection Timing: Draw blood no sooner than 12 hours (trough value) after last dose or immediately before next scheduled dose.

Synonyms

Amiodarone, Cordarone, Desethylamiodarone, Pacerone (Amiodarone Hydrochloride)

Components

Code	Name
RAMI	Amiodarone
RDAMI	Desethylamiodarone

Method: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Range: See individual components
Ref. Range Notes: Interpretation:

Clinical effects generally require serum concentrations above 0.5 mcg/mL.

Increased risk of toxicity is associated with amiodarone concentrations above 2.5 mcg/mL.

Although therapeutic and toxic ranges are based only on the parent drug, the active metabolite N-desethylamiodarone should be present in similar concentrations to amiodarone.
Interferences and Limitations: Cautions:

Numerous drug interactions have been observed for amiodarone. Clinical follow-up is essential for optimal use of amiodarone. Therapeutic drug monitoring for amiodarone and coadministered medications is highly recommended.

Specimens that are obtained from gel tubes or anticoagulate collections can cause assay interference.

Specimen Type: Blood
Collection: 5 mL blood in RED TOP tube

Unacceptable: GOLD SST/serum gel separator tube
Handling Instructions: Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 24 hours.
Quantity: Requested: 1.5 mL serum
Minimum: 0.5 mL serum

Receiving Instructions

Centrifuge within 2 hours of collection and aliquot serum into plastic vial. Refrigerate serum.

Sendouts:

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 24 hours.

Lab Department

Sendouts Mayo Lab (FZ)(MAFZ)

Frequency

Performed: Monday - Saturday. Report Available: 3-5 days.

Available STAT?

Performing Location(s)

Sendout	Mayo Clinic Laboratories (Superior Drive) 800-533-1710 3050 Superior Drive NW Rochester, MN 55901