Cryofibrinogen_Heparin (as part of cryofibrinogen package)

Cryofibrinogenemia refers to the presence of cold-precipitating proteins in plasma but not in serum, with results reported at 3 and 10 days. A semi-quantitative estimate of the amount of precipitate is reported when present. If a cryofibrinogen precipitate is present in both blue citrate and green heparin plasma tubes but not in serum, it is more likely to be clinically significant. Presence of cryofibrinogens in the peripheral blood can be asymptomatic, but is associated with a variety of conditions including malignancy, infection, systemic rheumatic diseases or thromboembolic disorders.

Precipitation (Passive precipitation at refrigerator temperature, that is reversible when warmed to 37°C)

False negative results if samples are not kept at 37°C between collection and cell separation step.

15 mL blood in GREEN TOP tube. Specimens must be maintained at 37°C

Keep ALL tubes at 37°C and transport to lab as IMMEDIATELY. Suggest transporting specimens under your arm with specimen tubes securely enclosed in a specimen transport bag. Specimens will be rejected if clotted. This test is NOT drawn on Blood draw rounds.