Anti Neuronal Cell Antibody

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General Information

Lab Name
Anti Neuronal Cell Ab
Lab Code
ANEUR
Epic Name
Anti Neuronal Cell Antibody
Description

Elevated serum or CSF anti-neuronal cell antibody levels may help in the diagnosis of neuropsychiatric systemic lupus erythematosus (SLE). This test should not be mistaken for the assay for anti-neuronal nuclear antibodies (ANNA), which include anti-Hu, Yo, and Ri antibodies. These other tests may be ordered to evaluate some forms of paraneoplastic peripheral neuropathies associated with various malignancies, and are not currently performed at the University of Washington (they are send-out tests).

    ***Order Alert: Effective 11/20/2025, serum and cerebrospinal anti-neuronal cell antibody testing is temporarily unavailable due to an assay reagent issue. The duration of the downtime is unknown, but clients will be informed once testing resumes. Please contact Client Support Services at 206-520-4600 for any questions.***

    References
    1. Ho RC, et al. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev 2016, 15:124-38. 26497108
    2. West SG, Emlen W, Wener MH, and Kotzin BL. Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 1995, 99:153-63. 7625420
    Components
    Code Name
    ANEU Anti Neuronal Cell Ab
    IINTP1 Interpretation
    ANMTH Anti Neuronal Cell Ab Method

    Interpretation

    Guidelines
    Method

    ELISA using stable, isolated neuronal membrane extracts.

    Reference Range
    See individual components
    Ref. Range Notes

    Established by testing healthy blood donor samples during method validation in 1987. Confirmed in 2005, 2010, 2012, 2015, and 2018.

    References
    1. Ho RC, et al. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev 2016, 15:124-38. 26497108
    2. West SG, Emlen W, Wener MH, and Kotzin BL. Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests. Am J Med 1995, 99:153-63. 7625420

    Ordering & Collection

    Specimen Type
    Blood
    Collection

    3 mL blood in RED TOP or SST tube

    Quantity
    Requested: 1 mL serum
    Minimum: 0.5 mL serum

    Processing

    Receiving Instructions

    Freeze serum at -20°C

    Stability: Freezer: Long Term; Refrig: 14 d

    Misc Sendout

    Performance

    Lab Department
    Immunology(IMM)
    Frequency
    Monday, Wednesday
    Available STAT?
    No
    Performing Location(s)
    UW-MT Immunology
    206-520-4600

    Clinical Lab, Room NW220,
    University of Washington Medical Center,
    1959 NE Pacific street, Seattle, WA 98195

    Billing & Coding

    CPT Codes
    83520
    LOINC
    32853-4
    Interfaced Order Code
    UOW156