Useful For:
Refer to Autoimmune Encephalitis Testing Recommendations for additional ordering guidance.
Test Algorithm: Refer to Mayo's algorithm (linked below) for additional detail on tests and potential reflex tests included in this panel. Reflex testing may be performed at additional charge.
Patient Preparation:
Panel tests and reflex tests use the following methods: Indirect Immunofluorescence Assay (IFA), Cell Binding Assay (CBA), Western blot (WB), Radioimmunoassay (RIA), Immunoblot (IB)
Reference Values:
AChR Ganglionic Neuronal Antibody: | < or =0.02 nmol/L |
Anti-Neuronal Nuclear Antibody, Type 1 (ANNA-1): | Negative |
Adaptor Protein 3 Beta2 (AP3B2) Antibody IFA: | Negative |
Contactin-Associated Protein-Like-2 (CASPR2) IgG Antibody CBA: | Negative |
Collapsin Response-Mediator Protein-5 (CRMP-5) IgG: | Negative |
Dipeptidyl Aminopeptidase-Like Protein 6 (DPPX) Antibody CBA: | Negative |
Leucine-Rich Glioma Inactivated Protein-1 IgG (LGI1) Antibody CBA: | Negative |
Purkinje Cell Cytoplasmic Antibody Type 2 (PCA-2): | Negative |
Note: Includes reference values for panel tests only.
Neuron-restricted patterns of IgG staining that do not fulfill criteria for ANNA-1, CRMP-5-IgG, or PCA-2 may be reported as "unclassified anti-neuronal IgG." Complex patterns that include nonneuronal elements may be reported as "uninterpretable."
CRMP-5 Note: CRMP-5 titers lower than 1:240 are detectable by recombinant CRMP-5 Western blot analysis. CRMP-5 Western blot analysis will be done on request on stored serum (held 4 weeks). This supplemental testing is recommended in cases of chorea, vision loss, cranial neuropathy, and myelopathy.
Collect 12 mL blood in RED TOP tubes or GOLD TOP SST
Outside Laboratories: Centrifuge samples and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Centrifuge samples and transfer serum to a separate plastic vial. Refrigerate serum.
Login: SEND1-;REFRIG
Sendouts:
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Sendout |
Mayo Clinic Laboratories
800-533-1710 200 First Street Southwest |
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CPTs: 83519, 86255x7