Neuroimmunology Antibody Follow-up, Serum (Sendout)

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General Information

Lab Name
Lab Code
982
External Test Id
PNEFS
Description

Useful For: Monitoring patients who have previously tested positive for 1 or more antibodies within the past 5 years in a Mayo Neuroimmunology Laboratory serum evaluation. Contact Mayo at 800-533-1710 to determine if a patient is eligible for Neuroimmunology Antibody Follow-up Testing.

Ordering Requirements:

  • This test is intended for follow-up testing only. It requires that the patient has had a previous positive result performed at Mayo for the same antibody that is being requested.
  • This test is not appropriate for new single antibody requests without a prior positive. Contact the Laboratory Medicine Resident (LMR) as needed to clarify the test request.
Synonyms
ACh Receptor (Muscle) Modulating Ab, AChR Ganglionic Neuronal Ab, AGNA-1, AMPA-R Ab, Amphiphysin Ab, ANNA-1, ANNA-2, ANNA-3, Anti-Glial Nuclear Ab, Anti-Neuronal Nuclear Ab Type 1, Anti-Neuronal Nuclear Ab Type 2, Anti-Neuronal Nuclear Ab Type 3, CASPR2-IgG, CRMP-5-IgG, DPPX Ab, GABA-B-R Ab, LGI1-IgG, mGluR1 Ab, N-Type Calcium Channel Ab, P/Q-Type Calcium Channel Ab, PCA-1, PCA-2, PCA-Tr, PNEFS, Purkinje Cell Cytoplasmic Ab Type 1, Purkinje Cell Cytoplasmic Ab Type 2, Purkinje Cell Cytoplasmic Ab Type Tr, Type 1

Interpretation

Method
  • Indirect Immunofluorescence (IFA): Anti-Neuronal Nuclear Ab, Type 1, Anti-Neuronal Nuclear Ab, Type 2, Anti-Neuronal Nuclear Ab, Type 3, Anti-Glial Nuclear Ab, Type 1, Purkinje Cell Cytoplasmic Ab Type 1, Purkinje Cell Cytoplasmic Ab Type 2, Purkinje Cell Cytoplasmic Ab Type Tr, Amphiphysin Ab, CRMP-5-IgG, AMPA-R Ab IF Titer Assay, GABA-B-R Ab IF Titer Assay, NMDA-R Ab IF Titer Assay, DPPX Ab IFA, DPPX Ab IFA Titer, mGluR1 Ab IFA Titer, mGluR1 Ab IFA.
  • Cell-Binding Assay (CBA): AMPA-R Ab CBA, CASPR2-IgG CBA, DPPX Ab CBA, GABA-B-R Ab CBA, LGI1-IgG CBA, mGluR1 Ab CBA, NMDA-R Ab CBA.
  • Radioimmunoassay (RIA): P/Q-Type Calcium Channel Ab, N-Type Calcium Channel Ab, AChR Ganglionic Neuronal Ab, Neuronal (V-G) K+ Channel Ab, ACh Receptor (Muscle) Modulating Ab.

Ordering & Collection

Specimen Type
Blood
Collection

12 mL blood in RED TOP tubes or GOLD SST

Handling Instructions
Quantity
requested: 4 mL serum
minimum: 2 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Login: SEND1-;REFRIG

  • RSNDT1: MAYO
  • RSTYP1: SRM
  • RTSTRQ1: ;Neuroimmunology Antibody Follow up, [Antibody Name]

Sendouts:

  • If unable to locate previous positive antibody results in MayoAccess, contact Mayo to determine if the patient is eligible for Neuroimmunology Antibody Follow-up Testing.
  • Order Mayo Test: PNEFS and specify the antibody or antibodies requested.

Stability: Refrigerated (Preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, lipemia, icterus.

Performance

LIS Dept Code
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901
Frequency
Performed: Varies (refer to Mayo website). Analytic Time: Varies.
Available STAT?
No

Billing & Coding

CPT codes
Billing Comments

CPTs: Varies based on test performed.

LOINC