Paraneoplastic Autoantibody Evaluation, CSF (Sendout)
General Information
- Lab Name
- Lab Code
- 782
- External Test Id
- PAC1
- Description
Useful For:
- Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens.
- For a complete list of tests and potential reflex tests included in this panel, refer to Mayo's algorithm linked below.
Ordering Guidance: The Paraneoplastic Autoantibody Evaluation is not the recommended test for patients suspected of autoimmune neurological disorders. A comprehensive neurological phenotype-specific autoimmune/paraneoplastic evaluation (e.g. encephalopathy, movement disorders, myelopathy, axonal neuropathy, etc.) should be considered. For additional guidance, review the Autoimmune Encephalitis Testing Recommendations or consult the Laboratory Medicine Resident on-call.
- Synonyms
- AGNA-1 CSF, Amphiphysin Antibody, ANNA-1, ANNA-2, ANNA-3, Anti-Glial Nuclear Ab Type 1, Anti-Neuronal Nuclear Ab Type 1, Anti-Neuronal Nuclear Ab Type 2, Anti-Neuronal Nuclear Ab Type 3, Collapsin Response-Mediator Protein-5 Antibody, CRMP-5 IgG, PAC1, PCA-1, PCA-2, PCA-Tr, Purkinje Cell Cytoplasmic Ab Type 1, Purkinje Cell Cytoplasmic Ab Type 2, Purkinje Cell Cytoplasmic Ab Type Tr
- Components
Interpretation
- Guidelines
- Method
Panel and reflex tests include the following methods: Indirect Immunofluorescence Assay (IFA), Western Blot (WB), Immunoblot (IB)
- Reference Range
- Ref. Range Notes
Reference Values:
Amphiphysin Antibody, CSF: Negative Anti-Glial Nuclear Antibody Type 1 (AGNA-1), CSF: Negative Anti-Neuronal Nuclear Antibody Type 1 (ANNA-1), CSF: Negative Anti-Neuronal Nuclear Antibody Type 2 (ANNA-2), CSF: Negative Anti-Neuronal Nuclear Antibody Type 3 (ANNA-3), CSF: Negative Collapsin Response-Mediator Protein-5 (CRMP-5) IgG Antibody, CSF: Negative Purkinje Cell Cytoplasmic Antibody Type Tr, CSF (PCA-Tr): Negative Purkinje Cell Cytoplasmic Antibody Type 1, CSF (PCA-1): Negative Purkinje Cell Cytoplasmic Antibody Type 2, CSF (PCA-2): Negative Note: Includes reference values for panel tests only.
Interpretation: Antibodies directed at onconeural proteins shared by neurons, glia, muscle, and certain cancers are valuable serological markers of a patient's immune response to cancer. They are not found in healthy subjects and are usually accompanied by subacute neurological signs and symptoms. Several autoantibodies have a syndromic association, but no autoantibody predicts a specific neurological syndrome. Conversely, a positive autoantibody profile has 80% to 90% predictive value for a specific cancer. It is not uncommon for more than one paraneoplastic autoantibody to be detected, each predictive of the same cancer.
Ordering & Collection
- Specimen Type
- CSF
- Collection
-
4 mL CSF in sterile vial
- Preferred: Vial number 2.
- Handling Instructions
Outside Laboratories: Refrigerate CSF in a sterile vial.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, icterus.
- Quantity
-
Requested: 4 mL CSF
Minimum: 2 mL CSF
Processing
- Receiving Instructions
Refrigerate CSF in a sterile vial.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: CSF
- RTSRQ1: ;Paraneoplastic Autoantibody Evaluation (Mayo Test PAC1)
Sendouts:
- Order Mayo test: PAC1.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, icterus.
- Misc Sendout
Performance
- Lab Department
- Frequency
- Performed: Monday through Sunday. Reflex tests: Varies. Report Available: 10-17 days.
- Available STAT?
- No
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901
Billing & Coding
- Billing Comments
CPTs: 86255x9
- Note: Includes panel tests only. Reflex testing may be added at additional charge.