Apolipoprotein E Genotyping, Cardiovascular Risk (Sendout)

General Information

Lab Name
Lab Code: 377
External Test Id: 2013337
Description: Ordering Recommendation: Provide supporting evidence for a diagnosis of type III hyperlipoproteinemia for evaluation of premature coronary heart disease.

Note: This test is not recommended for nonsymptomatic patients under 18 years of age.

Ordering Guidance: For ApoE testing to inform lecanemab therapy decisions, refer to separate test #1096, Apolipoprotein E (APOE) Genotyping, Lecanemab Therapy Risk (Sendout).
Synonyms: 2013337, Apo E Genotype, APOE, Apolipoprotein E Mutation Analysis

Method: Polymerase Chain Reaction/Fluorescence Monitoring
Ref. Range Notes: Reference Interval: Homozygous APOE e3 (e3/e3): This genotype is the most common (normal) genotype.
Interferences and Limitations: Limitations: Only the e2, e3 and e4 variants will be detected. Rare isoforms of APOE will not be detected. If rare alleles are suspected, phenotyping by isoelectric focusing may be indicated. Diagnostic errors can occur due to rare sequence variations.

Specimen Type: Blood
Collection: 3 mL blood in LAVENDER TOP (EDTA) tube

Also Accepted: Yellow (ACD Solution A or B) or Pink (K2EDTA)
Handling Instructions: Outside Laboratories: Refrigerate whole blood in original collection container.

Stability: Refrigerated (preferred): 1 week; Ambient: 72 hours; Frozen: 1 month.

Unacceptable Conditions: Plasma or serum. Heparinized specimens. Frozen specimens in glass collection tubes.
Quantity: requested: 3 mL whole blood
minimum: 1 mL whole blood

Processing

Refrigerate whole blood in original collection container.

Login: GSEND1-;REFRIG

Sendouts: order ARUP Test: 2013337.

Stability: Refrigerated (preferred): 1 week; Ambient: 72 hours; Frozen: 1 month.

Unacceptable Conditions: Plasma or serum. Heparinized specimens. Frozen specimens in glass collection tubes.

LIS Dept Code

Performing Location(s)

Sendout	ARUP Laboratories, Inc. 800-522-2787 500 Chipeta Way Salt Lake City, UT 84108

Frequency

Performed: Mon, Thurs. Reported: 2-7 days.

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