Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum (Sendout)
General Information
- Lab Name
- Lab Code
- 1086
- External Test Id
- MDS2
- Description
Useful For: Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, brainstem encephalitis, chorea, dyskinesias, myoclonus, and parkinsonism using serum specimens.
Testing Algorithm: Reflex testing may be performed at additional charge. Refer to Mayo's algorithm below.
Patient Preparation:
- For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
- This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.
Ordering Requirements: Laboratory Medicine Resident (LMR) approval is required.
- Synonyms
- Ataxia, Brainstem encephalitis, Chorea, Dyskinesias, MDS2, Myoclonus, Parkinsonism
Interpretation
- Method
Panel and reflex tests include the following methods: Indirect Immunofluorescence Assay (IFA), Cell Binding Assay (CBA), Radioimmunoassay (RIA), Immunoblot (IB), Western Blot (WB)
- Ref. Range Notes
Reference Ranges: See report.
Interpretation: A positive antibody result is consistent with a diagnosis of an autoimmune movement disorder. A search for cancer may be indicated, depending on the antibody profile. A trial of immune therapy may bring about improvement in neurological symptoms.
- Interferences and Limitations
Cautions:
A negative antibody test result does not exclude an autoimmune movement disorder.
Corticosteroid treatment prior to the serum collection may cause a false-negative result.
Intravenous immunoglobulin (IVIg) treatment prior to the serum collection may cause a false-positive result.
- Guidelines
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
Collect 12 mL blood in RED TOP tube or GOLD SST
- Approval Required
- Laboratory Medicine Resident (LMR) approval is required.
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
- Quantity
-
requested: 4 mL serum
minimum: 3 mL serum
Processing
- Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: SRM
- RTSRQ1: ;Movement Disorder, Autoimmune Paraneoplastic Eval, Serum (Mayo Test MDS2)
Sendouts:
- Order Mayo Test: MDS2.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, lipemia, or icterus.
Performance
- LIS Dept Code
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901 - Frequency
- Performed: Monday - Sunday. Report Available: 8 - 12 days.
- Available STAT?
- No
Billing & Coding
- CPT codes
- Billing Comments
Panel CPTs: 86596, 86255x25, 84182, 86341
If indicated, reflex testing may be performed at additional charge.
- LOINC