Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum (Sendout)

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General Information

Lab Name
Lab Code
1071
External Test Id
MAS1
Description

Useful For: Evaluating patients with suspected autoimmune myelopathy, myelitis, paraneoplastic myelopathy using serum specimens. Reflex testing may be performed at additional charge.

Patient Preparation:

  • For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
  • This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Ordering Requirements: Laboratory Medicine Resident (LMR) approval is required.

Synonyms
Anti-GFAP, Anti-MOG, MAS1, Neuromyelitis optica, Paraneoplastic myelopathy

Interpretation

Method

Varies: Indirect Immunofluorescence Assay (IFA), Radioimmunoassay (RIA), Western Blot (WB), Flow Cytometry (FCM); Cell-Binding Assay (CBA, reflex testing only).

Interferences and Limitations

Cautions:

Negative results do not exclude a diagnosis of autoimmune myelopathy.

Intravenous immunoglobulin (IVIg) treatment prior to the serum collection may cause a false-positive result.

Guidelines

Ordering & Collection

Specimen Type
Blood
Collection

12 mL blood in RED TOP tubes or GOLD SST

Approval Required
Laboratory Medicine Resident approval is required.
Handling Instructions

Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Quantity
requested: 4 mL serum
minimum: 2 mL serum

Processing

Processing

Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.

Login: SEND1-;REFRIG

  • RSNDT1: MAYO
  • RSTYP1: SRM
  • RTSRQ1: ;Myelopathy, Autoimmune Paraneoplastic Evaluation, Serum (Mayo Test MAS1)

Sendouts:

  • Order Mayo Test: MAS1.

Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.

Reject Due To: Gross hemolysis, gross lipemia, gross icterus.

Performance

LIS Dept Code
Performing Location(s)
Sendout Mayo Clinic Laboratories
800-533-1710

200 First Street Southwest
Rochester, MN 55901

Frequency
Performed: Monday - Sunday. Report Available: 10-13 days.
Available STAT?
No

Billing & Coding

CPT codes
Billing Comments

CPTs: 86255 x 12, 84182, 86341, 86363, 86053

  • Note: Includes panel tests only. Reflex testing may be added at additional charge.
LOINC