Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum (Sendout)
General Information
- Lab Name
- Lab Code
- 1071
- External Test Id
- MAS1
- Description
Useful For: Evaluating patients with suspected autoimmune myelopathy, myelitis, paraneoplastic myelopathy using serum specimens. Reflex testing may be performed at additional charge.
Patient Preparation:
- For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
- This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.
Ordering Requirements: Laboratory Medicine Resident (LMR) approval is required.
- Synonyms
- Anti-GFAP, Anti-MOG, MAS1, Neuromyelitis optica, Paraneoplastic myelopathy
Interpretation
- Method
Varies: Indirect Immunofluorescence Assay (IFA), Radioimmunoassay (RIA), Western Blot (WB), Flow Cytometry (FCM); Cell-Binding Assay (CBA, reflex testing only).
- Interferences and Limitations
Cautions:
Negative results do not exclude a diagnosis of autoimmune myelopathy.
Intravenous immunoglobulin (IVIg) treatment prior to the serum collection may cause a false-positive result.
- Guidelines
Ordering & Collection
- Specimen Type
- Blood
- Collection
-
12 mL blood in RED TOP tubes or GOLD SST
- Approval Required
- Laboratory Medicine Resident approval is required.
- Handling Instructions
Outside Laboratories: Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
- Quantity
-
requested: 4 mL serum
minimum: 2 mL serum
Processing
- Processing
Centrifuge sample and transfer serum to a separate plastic vial. Refrigerate serum.
Login: SEND1-;REFRIG
- RSNDT1: MAYO
- RSTYP1: SRM
- RTSRQ1: ;Myelopathy, Autoimmune Paraneoplastic Evaluation, Serum (Mayo Test MAS1)
Sendouts:
- Order Mayo Test: MAS1.
Stability: Refrigerated (preferred): 28 days; Frozen: 28 days; Ambient: 72 hours.
Reject Due To: Gross hemolysis, gross lipemia, gross icterus.
Performance
- LIS Dept Code
- Performing Location(s)
-
Sendout Mayo Clinic Laboratories
800-533-1710200 First Street Southwest
Rochester, MN 55901 - Frequency
- Performed: Monday - Sunday. Report Available: 10-13 days.
- Available STAT?
- No
Billing & Coding
- CPT codes
- Billing Comments
CPTs: 86255 x 12, 84182, 86341, 86363, 86053
- Note: Includes panel tests only. Reflex testing may be added at additional charge.
- LOINC