Copeptin proAVP (Sendout)

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General Information

Lab Name
Copeptin proAVP
Lab Code
RCOPEP
Epic Name
Copeptin proAVP (Sendout)
External Test Id
CPAVP
Description

Useful For:

  • Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status
  • May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers
  • Note: Copeptin is superior to arginine vasopressin in the diagnosis of diabetes insipidis due to its longer half-life.

Patient Preparation: For water-deprived testing, have the patient fast and thirst for at least 8 hours (no liquids, including water, are allowed).

Synonyms
ADH, Antidiuretic Hormone, Arginine Vasopressin Hormone, AVH, CPAVP, Diabetes Insipidus, RAVPH, Vasopressin
Components

Interpretation

Method

Immunofluorescent Assay (IFA)

Reference Range
Units: pmol/L
Ref. Range Notes

Reference Values:

Non-water deprived, non-fasting adults: <13.1 pmol/L
Water deprived, fasting adults: <15.2 pmol/L
Non-water deprived, non-fasting pediatric patients: <14.5 pmol/L
Interferences and Limitations

Cautions:

Sepsis, severe sepsis, septic shock, lower respiratory tract infections, chronic obstructive pulmonary disease, and cardiovascular diseases, eg, chronic heart failure may increase copeptin concentrations.

Arginine vasopressin (AVP) receptor antagonist therapies and other diseases in which AVP has been shown to play an important pathophysiologic role may also increase copeptin concentration.

In some cases, bronchial carcinoma may lead to ectopic copeptin secretion.

Mixed forms of diabetes insipidus (DI) can exist, and both central and peripheral DI may be incomplete, complicating the interpretation of results.

In rare cases, some individuals can develop antibodies to mouse or other animal antibodies (often referred to as human anti-mouse antibodies [HAMA] or heterophile antibodies), which may cause interference in some immunoassays. Caution should be used in interpretation of results and the laboratory should be alerted if the result does not correlate with the clinical presentation.

Ordering & Collection

Specimen Type
Blood
Collection

2 mL Blood in LAVENDER TOP (EDTA) Tube

Handling Instructions

Outside Laboratories: Centrifuge sample and transfer plasma to a separate plastic vial. Refrigerate plasma.

Stability: Refrigerated (preferred): 7 days; Frozen: 30 days; Ambient: 7 days.

Reject Due To: Gross hemolysis.

Quantity
Requested: 0.5 mL plasma
Minimum: 0.3 mL plasma

Processing

Receiving Instructions

Centrifuge sample and transfer plasma to a separate plastic vial. RefrIgerate serum.

Sendouts:

  • Order Mayo Test: CPAVP.
  • Interfaced: Yes.

Stability: Refrigerated (preferred): 7 days; Frozen: 30 days; Ambient: Unacceptable.

Reject Due To: Gross hemolysis.

Misc Sendout

Performance

Lab Department
Sendouts Mayo Lab (RF)(MARF)
Frequency
Performed: Monday-Saturday. Reported: 1-3 days from sample receipt at Mayo Clinic Laboratories.
Available STAT?
No
Performing Location(s)
Sendout Mayo Clinic Laboratories (Superior Drive)
800-533-1710

3050 Superior Drive NW
Rochester, MN 55901

Billing & Coding

CPT Codes
84588
LOINC
78987-5
Interfaced Order Code
UOW3670
Interfaced Result Code
UOW3670